Hsp17 thermometer explained

Hsp17 thermometer
Rfam:	RF02358
Tax Domain:	Bacteria

In molecular biology, the Hsp17 thermometer is an RNA element (RNA thermometer) found in the 5' UTR of Hsp17 mRNA.^[1] Hsp17 is a cyanobacterial heat shock protein belonging to the Hsp20 family.^[2]

At physiological temperature (28 degrees Celsius) the Hsp17 thermometer forms a hairpin structure, preventing translation of Hsp17. Under heat shock conditions the hairpin structure melts and translation takes place.

See also

• RNA thermometer
• ROSE element
• FourU thermometer
• Hsp90 cis-regulatory element
• Cyanobacterial RNA thermometers

Notes and References

1. Kortmann J, Sczodrok S, Rinnenthal J, Schwalbe H, Narberhaus F . Translation on demand by a simple RNA-based thermosensor. . Nucleic Acids Res . 2011 . 39 . 7 . 2855–2868 . 21131278 . 10.1093/nar/gkq1252 . 3074152 .
2. Török Z, Goloubinoff P, Horváth I, Tsvetkova NM, Glatz A, Balogh G, etal . Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding. . Proc Natl Acad Sci U S A . 2001 . 98 . 6 . 3098–3103 . 11248038 . 10.1073/pnas.051619498 . 30613 . free .