Howell-Jolly body-like inclusions explained

Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis.[1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. The term was coined in 1989.[2]

They are most often observed in neutrophils, but can also appear in monocytes, lymphocytes, eosinophils.[2]

They may appear in patients on immunosuppression and antiviral therapies with nucleoside analogs, anticancer chemotherapeutic agents, active COVID-19 infections, HIV/AIDS, and myelodysplastic syndrome. [3] [1]

Notes and References

  1. Morphology of Blood Cells . Blood Cells: A Practical Guide . 9 June 2006 . 61–174 . 10.1002/9780470987551.ch3. 978-1-4051-4265-6 .
  2. Oehadian . A . Huang . I . Kartikasari . A . Alisjahbana . B . Prihatni . D . Howell-Jolly Body-Like Inclusions in Coronavirus Disease 2019 (COVID-19): Possible Novel Findings. . Journal of Blood Medicine . 2023 . 14 . 233–238 . 10.2147/JBM.S399596 . free . 37016662. 10066893 .
  3. Tong . YT . Nguyen . ND . Wahed . A . Howell-Jolly Body-Like Inclusions in Neutrophils of Patients With Myelodysplastic Syndrome: A Novel Correlation. . Archives of Pathology & Laboratory Medicine . January 2019 . 143 . 1 . 112–114 . 10.5858/arpa.2017-0328-OA . 30059259. free .

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