| House of the Little Sisters of the Poor | |
| Native Name: | Asilo de Hermanitas de los Pobres |
| Native Language: | Spanish |
| Coordinates: | 40.4224°N -3.6681°W |
| Location: | Madrid, Spain |
| Architect: | Ricardo García Guereta |
| Designation1: | Spain |
| Designation1 Offname: | Asilo de Hermanitas de los Pobres |
| Designation1 Type: | Non-movable |
| Designation1 Criteria: | Monument |
| Designation1 Date: | 1996 |
| Designation1 Number: | RI-51-0009578 |
The House of the Little Sisters of the Poor (Spanish: Asilo de Hermanitas de los Pobres), also known as Mi Casa, is a residence for elderly people in the Salamanca district of Madrid, Spain. It is run by the Little Sisters of the Poor, who also run a similarly named facility in the Chamberi district.
The building was designed by Ricardo Garcia Guereta, and has neo-mudejar features.