| Official Name: | Horse Creek, South Dakota |
| Settlement Type: | Census-designated place |
| Pushpin Map: | South Dakota#USA |
| Pushpin Label: | Horse Creek |
| Coordinates: | 43.5381°N -100.7381°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Dakota |
| Subdivision Type2: | County |
| Subdivision Name2: | Mellette |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 0.95 |
| Area Land Sq Mi: | 0.95 |
| Area Water Sq Mi: | 0.00 |
| Area Total Km2: | 2.46 |
| Area Land Km2: | 2.46 |
| Area Water Km2: | 0.00 |
| Population As Of: | 2020 |
| Population Footnotes: | [2] |
| Population Density Km2: | 75.99 |
| Timezone: | Mountain (MST) |
| Utc Offset: | -7 |
| Timezone Dst: | MDT |
| Utc Offset Dst: | -6 |
| Elevation Ft: | 2005 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 57579 (White River) |
| Area Code: | 605 |
| Blank Name: | FIPS code |
| Blank Info: | 46-30056 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2813051 |
| Population Total: | 187 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 196.84 |
Horse Creek is an unincorporated community and census-designated place (CDP) in Mellette County, South Dakota, United States. It was first listed as a CDP prior to the 2020 census. The population of the CDP was 187 at the 2020 census.[3]
It is in the central part of the county, 2miles south of White River, the county seat. The Little White River flows from north to south through the CDP, with most of the community's development to the east of the river on high ground.
U.S. Route 83 runs along the eastern edge of the CDP, leading north through White River to Interstate 90 at Murdo and south to Mission. South Dakota Highway 44 leads east-southeast from the CDP to Winner. Highway 44 follows US 83 north to White River, then turns west and leads to Interior, near Badlands National Park.