Horrilysin Explained

Horrilysin
Ec Number:3.4.24.47
Cas Number:84056-81-5

Horrilysin (Crotalus horridus metalloendopeptidase, hemorrhagic proteinase IV, Crotalus horridus horridus venom hemorrhagic proteinase) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Cleavage of only the single bond Ala14-Leu in the insulin B chain, Ser12-Leu in the A chain, and Ile-Gly, Pro-Ala, and Ser-Trp in melittin

This endopeptidase is present in the venom of the timber rattlesnake (Crotalus horridus horridus)

Notes and References

  1. Civello DJ, Duong HL, Geren CR . Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom . Biochemistry . 22 . 4 . 749–55 . February 1983 . 6340728 . 10.1021/bi00273a007 .
  2. Civello DJ, Moran JB, Geren CR . Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom . Biochemistry . 22 . 4 . 755–62 . February 1983 . 6340729 . 10.1021/bi00273a008 .

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