The Hornby Baronetcy, of Brookhouse in the Parish of Saint Michael, Blackburn, in the County Palatine of Lancaster, was a title in the Baronetage of the United Kingdom. It was created on 21 February 1899 for William Hornby, commonly known as Harry Hornby, who was for many years a Conservative member of parliament for Blackburn. His father, William Henry Hornby (1805–1884), had been a successful industrialist and a Conservative parliamentarian, holding a Blackburn seat from 1857 to 1865; his brother Edward Hornby held a seat in Blackburn from 1869 to 1874.
The title became extinct on the death of the second baronet, Henry Russell Hornby, in 1971.