| Official Name: | Horcajo Medianero |
| Settlement Type: | Municipality |
| Flag Size: | 150 |
| Coordinates: | 40.6403°N -5.4064°W |
| Subdivision Type: | Country |
| Subdivision Name: | Spain |
| Subdivision Type1: | Autonomous community |
| Subdivision Name1: | Castile and León |
| Subdivision Type2: | Province |
| Subdivision Name2: | Salamanca |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | Tierra de Alba |
| Leader Party: | PSOE |
| Leader Title: | Mayor |
| Leader Name: | Carlos José Sánchez Martín |
| Area Footnotes: | [1] |
| Area Total Km2: | 53 |
| Elevation M: | 1008 |
| Population Density Km2: | auto |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Postal Code Type: | Postal code |
| Postal Code: | 37860 |
Horcajo Medianero is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon. It is located from the provincial capital city of Salamanca and has a population of 329 people.
The municipality covers an area of 53km2. It lies above sea level and the postal code is 37860.