Hopeahainol A Explained
Hopeahainol A is a polyphenol acetylcholinesterase inhibitor with the molecular formula C56H42O12.[1] [2] [3] Hopeahainol A has been isolated from the tree Hopea hainanensis.[3] Hopeahainol A may be used for the treatment of Alzheimer's disease.[4]
Further reading
- Nicolaou . K. C. . Kang . Qiang . Wu . T. Robert . Lim . Chek Shik . Chen . David Y.-K. . Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A . Journal of the American Chemical Society . 2 June 2010 . 132 . 21 . 7540–7548 . 10.1021/ja102623j. 20462209 .
- Book: Chang . Raymond Chuen-Chung . Advanced Understanding of Neurodegenerative Diseases . 16 December 2011 . BoD – Books on Demand . 978-953-307-529-7 . 170 . en.
Notes and References
- Rosenberry . Terrone L. . Martin . Patricia K. . Nix . A. Jeremy . Wildman . Scott A. . Cheung . Jonah . Snyder . Scott A. . Tan . Ren Xiang . Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence . Chemico-Biological Interactions . November 2016 . 259 . Pt B . 78–84 . 10.1016/j.cbi.2016.05.032. 27297626 . 5136322 .
- Book: Wiart . Christophe . Medicinal Plants of China, Korea, and Japan: Bioresources for Tomorrow's Drugs and Cosmetics . 11 May 2012 . CRC Press . 978-1-4398-9912-0 . 229 . en.
- Ge . Hui Ming . Zhu . Chun Hua . Shi . Da Hua . Zhang . Li Dong . Xie . Dai Qian . Yang . Jie . Ng . Seik Weng . Tan . Ren Xiang . Hopeahainol A: An Acetylcholinesterase Inhibitor from Hopea hainanensis . Chemistry - A European Journal . January 2008 . 14 . 1 . 376–381 . 10.1002/chem.200700960. 17943703 .
- Book: Zografos . Alexandros L. . From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products . 18 April 2016 . John Wiley & Sons . 978-1-118-75173-2 . 370 . en.
