Homotopic connectivity explained

In biology, homotopic connectivity is the connectivity between mirror areas of the human brain hemispheres.^[1]

Changes in the homotopic connectivity occur in disorders such as melancholic depression,^[2] major depressive disorder,^[3] schizophrenia^[4] and cortical seizures.^[5]

Notes and References

1. Mancuso L, Costa T, Nani A, Manuello J, Liloia D, Gelmini G, Panero M, Duca S, Cauda F . 6 . The homotopic connectivity of the functional brain: a meta-analytic approach . Scientific Reports . 9 . 1 . 3346 . March 2019 . 30833662 . 10.1038/s41598-019-40188-3 . 6399443 . 2019NatSR...9.3346M .
2. Shan X, Cui X, Liu F, Li H, Huang R, Tang Y, Chen J, Zhao J, Guo W, Xie G . 6 . Shared and distinct homotopic connectivity changes in melancholic and non-melancholic depression . Journal of Affective Disorders . 287 . 268–275 . May 2021 . 33799047 . 10.1016/j.jad.2021.03.038 . 232775109 .
3. Hermesdorf M, Sundermann B, Feder S, Schwindt W, Minnerup J, Arolt V, Berger K, Pfleiderer B, Wersching H . 6 . Major depressive disorder: Findings of reduced homotopic connectivity and investigation of underlying structural mechanisms . Human Brain Mapping . 37 . 3 . 1209–1217 . March 2016 . 26704348 . 6867499 . 10.1002/hbm.23097 .
4. Li HJ, Xu Y, Zhang KR, Hoptman MJ, Zuo XN . Homotopic connectivity in drug-naïve, first-episode, early-onset schizophrenia . Journal of Child Psychology and Psychiatry, and Allied Disciplines . 56 . 4 . 432–443 . April 2015 . 25130214 . 4333112 . 10.1111/jcpp.12307 .
5. Rossi LF, Wykes RC, Kullmann DM, Carandini M . Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity . Nature Communications . 8 . 1 . 217 . August 2017 . 28794407 . 10.1038/s41467-017-00159-6 . 5550430 . 2017NatCo...8..217R .