| Hombolo Makulu | |
| Native Name: | Kata ya Hombolo Makulu |
| Native Name Lang: | sw |
| Settlement Type: | Ward |
| Pushpin Map: | Tanzania |
| Coordinates: | -5.9°N 92°W |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Dodoma Region |
| Subdivision Type2: | District |
| Subdivision Name2: | Dodoma Urban |
| Subdivision Type3: | Ward |
| Subdivision Name3: | Hombolo Makulu |
| Leader Title1: | MP |
| Leader Name1: | Antony Mavunde |
| Leader Title2: | Mayor |
| Leader Name2: | Professor Davis G. Mwamfupe |
| Leader Title3: | Councilor |
| Leader Name3: | Yoram Jacob Lemanya |
| Population As Of: | 2016 |
| Population Total: | 9,659 |
| Timezone: | EAT |
| Utc Offset: | +3 |
Hombolo Makulu is an administrative ward in the Dodoma Urban district of the Dodoma Region of Tanzania. In 2016 the Tanzania National Bureau of Statistics report there were 9,659 people in the ward.