Homarylamine Explained

Homarylamine (INN;^[1] also known as 3,4-methylenedioxy-N-methylphenethylamine and MDMPEA) is an antitussive (anti-cough) drug^[2] which was patented in 1956 by Merck & Co., but has never been used medically as such.

Chemically it is a substituted phenethylamine. It is the N-methylated analog of methylenedioxyphenethylamine (MDPEA). It is a schedule I drug in the USA as a positional isomer of MDA.

Reactions

Reaction of homoarylamine with formaldehyde gives hydrastinine.

See also

• Hydrastine, an alkaloid derivative of homarylamine

Notes and References

1. International Non-Proprietary Names for Pharmaceutical Preparations. Chronicle of the World Health Organization . 1958 . 12 . 3 .
2. Stefko PL, Denzel J, Hickey I . Experimental Investigation of Nine Antitussive Drugs . Journal of Pharmaceutical Sciences . March 1961 . 50 . 3 . 216–221 . 10.1002/jps.2600500309.