| Holy Cross High School | |
| Type: | Private, Coed |
| Grades: | 9–12 |
| Conference: | Catholic High School League |
| Nickname: | Crusaders |
| Colors: | Blue and White |
| Closed: | 1989 |
| Location: | Marine City, Michigan, St. Clair County |
| Country: | USA |
Holy Cross High School was a coeducational Catholic high school in Marine City, Michigan, United States. It closed in 1989 but reopened the following year as Cardinal Mooney Catholic High School.[1] [2]