| Holitna River | |
| Map Size: | 300 |
| Pushpin Map: | USA Alaska |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of the mouth of the Holitna River in Alaska |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Alaska |
| Subdivision Type4: | Census Area |
| Subdivision Name4: | Dillingham, Bethel |
| Length: | 110miles |
| Source1: | confluence of Kogrukluk River and Shotgun Creek |
| Source1 Location: | east flank of the Kuskokwim Mountains, Dillingham Census Area |
| Source1 Coordinates: | 60.8497°N -157.8489°W |
| Source1 Elevation: | 376feet[1] |
| Mouth: | Kuskokwim River |
| Mouth Location: | 1.5miles south of Sleetmute, Bethel Census Area |
| Mouth Coordinates: | 61.6811°N -157.1686°W[2] |
| Mouth Elevation: | 190feet |
The Holitna River (Deg Xinag: Xaletno, Yup'ik: Rruulitnaq) is a 110miles tributary of the Kuskokwim River in the U.S. state of Alaska.[2] Formed by the confluence of Shotgun Creek and the Kogrukluk River east of the Kuskokwim Mountains, the river flows generally northeast to meet the larger river near Sleetmute.[2]
Operation Holitna, a federal investigation into child pornography, was named after the river.[3] The Holitna River has many tributaries, serving as a metaphor for the fact that each time the investigation makes an arrest, several new victims and leads are discovered.[4]