Holin superfamily VI explained

The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.

The Holin superfamily VI includes two TC families:^[1]

• 1.E.12 - The φAdh Holin (φAdh Holin) Family
• 1.E.26 - The Holin LLH (Holin LLH) Family

Superfamily VI includes families with members only from Bacillota. These proteins appear to have one N-terminal transmembrane segment (TMS), followed by an amphipathic, weakly hydrophobic peak that was not predicted to be transmembrane by the topological programs used by Reddy and Saier (2013).^[2] The average sizes of the members of the two families belonging to the Holin superfamily VI are 135 ± 11 and 130 ± 26 amino acyl residues (aas), respectively.

See also

• Holin
• Lysin
• Transporter Classification Database

Notes and References

1. Web site: Holin Superfamily VI. Transporter Classification Database. 2016-03-20.
2. Reddy. Bhaskara L.. Saier Jr.. Milton H.. 2013-11-01. Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828. 11. 2654–2671. 10.1016/j.bbamem.2013.07.004. 3788059. 23856191.