Holin superfamily V explained

The Holin superfamily V is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily V includes the TC families:^[1]

• 1.E.21 - The Listeria Phage A118 Holin (Hol118) Family
• 1.E.29 - The Holin Hol44 (Hol44) Family

Superfamily V includes protein families classified in the Transporter Classification Database as TC# 1.E.21 and TC# 1.E.29. Both families possess members from Bacillota, Actinomycetota and Chloroflexota. Proteins of this superfamily all appear to have 3 transmembrane segments (TMSs) and have average sizes of 97 and 101 amino acyl residues (aas), respectively.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Notes and References

1. Web site: Holin Superfamily V. Transporter Classification Database. 2016-03-20.
2. Reddy. Bhaskara L.. Saier Jr.. Milton H.. 2013-11-01. Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828. 11. 2654–2671. 10.1016/j.bbamem.2013.07.004. 3788059. 23856191.