Holbein is an organized hamlet in Saskatchewan that lies within the Rural Municipality of Shellbrook No. 493.
In the 2021 Census of Population conducted by Statistics Canada, Holbein had a population of 122 living in 48 of its 54 total private dwellings, a change of from its 2016 population of 109. With a land area of, it had a population density of in 2021.[1]