Hol-Tox family explained

The putative holin-like toxin (Hol-Tox) family (TC# 1.E.42) consists of many small proteins, between 34 and 48 amino acyl residues (aas) with a single transmembrane segment (TMSs). Rajesh et al. (2011) first identified the gene and designated it tmp1, which coded for a 34 amino acyl peptide that acts as an antibacterial agent on gram-positive bacteria.^[1] This peptide exhibits a single transmembrane domain (TMD) that is believed to play a role in facilitating the antibacterial activity. A representative list of proteins belonging to the Hol-Tox family can be found in the Transporter Classification Database.^[2]

See also

• Holin
• Lysin

Further reading

• Reddy . Bhaskara L. . Saier Jr . Milton H. . 2013 . Topological and phylogenetic analyses of bacterial holin families and superfamilies . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1828 . 11. 2654–2671 . 10.1016/j.bbamem.2013.07.004 . 23856191 . 3788059 .
• Saier . Milton H. . Reddy . Bhaskara L. . 2015 . Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications . Journal of Bacteriology . 197 . 1. 7–17 . 10.1128/JB.02046-14 . 25157079 . 4288690 .
• Wang . I. N. . Smith . D. L. . Young . R. . 2000 . Holins: the protein clocks of bacteriophage infections . Annual Review of Microbiology . 54 . 799–825 . 10.1146/annurev.micro.54.1.799 . 11018145 .
• Young . R. . Bläsi . U. . 1995 . Holins: form and function in bacteriophage lysis . FEMS Microbiology Reviews . 17 . 1–2. 191–205 . 10.1111/j.1574-6976.1995.tb00202.x . 7669346 .

Notes and References

1. Rajesh. Thangamani. Anthony. Thangamani. Saranya. Subramani. Pushpam. Paul Lavanya. Gunasekaran. Paramasamy. 2011-02-01. Functional characterization of a new holin-like antibacterial protein coding gene tmp1 from goat skin surface metagenome. Applied Microbiology and Biotechnology. 89. 4. 1061–1073. 10.1007/s00253-010-2907-6. 1432-0614. 20927512. 9315098.
2. Web site: 1.E.42 The Putative Holin-like Toxin (Hol-Tox) Family. TCDB. 2016-03-28.