| histidine-tRNA ligase | |
| Altnames: | histidyl tRNA synthetase, Jo-1 |
| Ec Number: | 6.1.1.21 |
| Cas Number: | 9068-78-4 |
| Go Code: | 0004821 |
In enzymology, a histidine-tRNA ligase is an enzyme that catalyzes the chemical reaction
ATP + L-histidine + tRNAHis
\rightleftharpoons
The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).
This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.
Histidine—tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.