Histatin 1 Explained

Histatin-1 is a protein that in humans is encoded by the HTN1 gene.^[1]

Further reading

• Sugiyama K, Ogino T, Ogata K . Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva. . Arch. Oral Biol. . 35 . 6 . 415–9 . 1990 . 2372245 . 10.1016/0003-9969(90)90202-L .
• Sabatini LM, Azen EA . Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). . Biochem. Biophys. Res. Commun. . 160 . 2 . 495–502 . 1989 . 2719677 . 10.1016/0006-291X(89)92460-1 .
• vanderSpek JC, Wyandt HE, Skare JC, etal . Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. . Am. J. Hum. Genet. . 45 . 3 . 381–7 . 1989 . 2773933 . 1683406 .
• Oppenheim FG, Xu T, McMillian FM, etal . Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. . J. Biol. Chem. . 263 . 16 . 7472–7 . 1988 . 10.1016/S0021-9258(18)68522-9 . 3286634 . free .
• Oppenheim FG, Yang YC, Diamond RD, etal . The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion. . J. Biol. Chem. . 261 . 3 . 1177–82 . 1986 . 10.1016/S0021-9258(17)36072-6 . 3944083 . free .
• Sabatini LM, Ota T, Azen EA . Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. . Mol. Biol. Evol. . 10 . 3 . 497–511 . 1993 . 8336540 . 10.1093/oxfordjournals.molbev.a040022. free .
• Driscoll J, Zuo Y, Xu T, etal . Functional comparison of native and recombinant human salivary histatin 1. . J. Dent. Res. . 74 . 12 . 1837–44 . 1996 . 8600179 . 10.1177/00220345950740120601. 10.1.1.532.5059 . 38609550 .
• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF . Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. . J. Dent. Res. . 79 . 2 . 732–9 . 2000 . 10728974 . 10.1177/00220345000790020601 . 27558675 .
• Flora B, Gusman H, Helmerhorst EJ, etal . A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation. . Protein Expr. Purif. . 23 . 1 . 198–206 . 2002 . 11570863 . 10.1006/prep.2001.1493 .
• Tamaki N, Tada T, Morita M, Watanabe T . Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1. . Calcif. Tissue Int. . 71 . 1 . 59–62 . 2003 . 12060866 . 10.1007/s00223-001-1084-0 . 38221230 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yin A, Margolis HC, Grogan J, etal . Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins. . Arch. Oral Biol. . 48 . 5 . 361–8 . 2003 . 12711380 . 10.1016/S0003-9969(03)00012-8 .
• Michels AA, Nguyen VT, Fraldi A, etal . MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. . Mol. Cell. Biol. . 23 . 14 . 4859–69 . 2003 . 12832472 . 10.1128/MCB.23.14.4859-4869.2003 . 162212 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bruno LS, Li X, Wang L, etal . Two-hybrid analysis of human salivary mucin MUC7 interactions. . Biochim. Biophys. Acta . 1746 . 1 . 65–72 . 2005 . 16203048 . 10.1016/j.bbamcr.2005.08.007 . free .
• Cabras T, Fanali C, Monteiro JA, etal . Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland. . J. Proteome Res. . 6 . 7 . 2472–80 . 2007 . 17503797 . 10.1021/pr0700706 .

Notes and References

1. Web site: Entrez Gene: HTN1 histatin 1.