Hisega is an unincorporated community in Pennington County, in the U.S. state of South Dakota.
A post office called Hisega was established in 1913, and remained in operation until 1945.[1] The post office may have operated during the summer season only. Hisega is an acronym formed from the names of these local women: Helen, Ida, Sadie, Ethel, Grace, and Ada.[2]