Hippulin Explained

Hippulin, also known as Δ⁸-14-isoestrone, as well as 14-isoestra-1,3,5(10),8-tetraen-3-ol-17-one, is a naturally occurring estrogen found in horses and an isomer of equilin.^{[1] [2] [3] [4]} The compound, likely in sodium sulfate form, is a component of conjugated estrogens (Premarin), a pharmaceutical extract of the urine of pregnant mares, though it is present only in small amounts in pregnant mare urine.^[5] It has been reported by possess either equivalent estrogenic activity to that of equilin or only slight estrogenic activity. The compound was first described in 1932.

See also

• List of estrogens § Equine estrogens

Notes and References

1. Book: C. W. Emmens. Hormone Assay. 22 October 2013. Elsevier Science. 978-1-4832-7286-3. 391–.
2. Book: H.J. Buchsbaum. The Menopause. 6 December 2012. Springer Science & Business Media. 978-1-4612-5525-3. 56–.
3. Banes D, Carol J, Haenni EO . The resolution of isoequilin A and the identification of compound 3 . J. Biol. Chem. . 187 . 2 . 557–70 . 1950 . 10.1016/S0021-9258(18)56200-1 . 14803438 . free .
4. Girard, H., Sandulesco, G., Fridenson, A., Gaudefroy, C., & Rutgers, J. J. (1932). Sur les Hormones Sexuelles Cristallisées Retirées de l'Urine des Juments Gravides. Compt. Rend. Acad. Sci, 194, 1020.
5. Wintersteiner. O.. Estrogenic Diols from the Urine of Pregnant Mares. Cold Spring Harbor Symposia on Quantitative Biology. 5. 1937. 25–33. 0091-7451. 10.1101/SQB.1937.005.01.003. 81202266 .