Hippo Branch is a stream in Ralls County in the U.S. state of Missouri. It is a tributary of Spencer Creek. The stream headwaters arise just southeast of Missouri Route 19 (at 39.4581°N -91.5797°W) and it flows east-southeast to its confluence with Spencer Creek one mile east of Madisonville (at 39.4644°N -91.48°W).[1]
According to tradition, "hippo" is a contraction of "hypochondria"; the story continues Hippo Branch was so named on account of a hypochondriac in the area.[2]