Hinsberg oxindole synthesis explained

The Hinsberg oxindole synthesis is a method of preparing oxindoles from the bisulfite additions of glyoxal.^{[1] [2]} It is named after its inventor Oscar Hinsberg.^{[3] [4] [5]}

See also

• Friedel-Crafts alkylation
• Stolle synthesis
• Hinsberg reaction

References

1. Book: Elderfield, R.C. . Heterocyclic Compounds . 3. 1952. New York. 139.
2. Murthy. Sabbavarapu Narayana. Madhav. Bandaru. Nageswar. Yadavalli Venkata Durga. Revisiting the Hinsberg Reaction: Facile and Expeditious Synthesis of 3-Substituted Quinoxalin-2(1H)-ones under Catalyst-Free Conditions in Water. Helvetica Chimica Acta. 15 June 2010. 93. 6. 1216–1220. 10.1002/hlca.200900358.
3. Hinsberg, O. . Ber. Dtsch. Chem. Ges.. 1888. 21. 110. 10.1002/cber.18880210122. Ueber die Einwirkung der Natriumbisulfitverbindung des Glyoxals auf aromatische Monamine.
4. Hinsberg. O.. Simeoff. A.. Synthese von Naphtindolderivaten. Berichte der Deutschen Chemischen Gesellschaft. January 1898. 31. 1. 250–254. 10.1002/cber.18980310150.
5. Hinsberg, O. . Ber. Dtsch. Chem. Ges.. 1908. 41. 1367. 10.1002/cber.190804101252. Über Glykokoll und Indol-derivate.