Hilmar Bading Explained

Hilmar Bading (born 1958) is a German physician and neuroscientist. He is a member of the German National Academy of Science Leopoldina.

Education and career

Hilmar Bading studied medicine from 1978 to 1984 at Heidelberg University (MD in 1984) and carried out his MD Thesis at the Max Planck Institute for Medical Research, Heidelberg on calcium transport ATPase in skeletal muscle. He received postdoctoral training at the Max Planck Institute for Molecular Genetics, Berlin, Germany (1985–1989) and at Harvard Medical School, Boston, US (1989–1993). From 1993 to 2001 he was a staff scientist at the MRC Laboratory of Molecular Biology, Cambridge, UK. Since 2001 he has been professor of neurobiology and director of the Neurobiology Institute and the Interdisciplinary Center for Neurosciences (IZN) at Heidelberg University.[1] [2]

He is co-founder of FundaMental Pharma GmbH, Heidelberg.[3]

He founded the Foundation BrainAid.[4]

Research

Hilmar Bading's work is focused on neuronal calcium signaling and gene regulation in the nervous system.[5] He identified calcium as the principal second messenger in the coupling of neuronal activity to gene expression and characterized the processes that mediate the dialogue between the synapse and the nucleus.[6] [7] His work highlighted the spatial aspects of calcium signals[8] [9] and in particular the importance of nuclear calcium in governing activity-dependent gene expression and adaptations in the nervous system that include memory formation and acquired neuroprotection.[10] [11] [12] The discovery of toxic signaling by extrasynaptic NMDA receptors which antagonizes gene regulation by synaptic activity and causes neuronal dysfunction and cell death[13] [14] contributed to the understanding of neurodegenerative disorders including Huntington's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS).[14] [15] [16] [17] [18]

Hilmar Bading and his co-workers uncovered the importance of a death signaling complex consisting of extrasynaptic NMDA receptors (NMDARs) and TRPM4 for excitotoxicity and identified a class of neuroprotective small molecules (known as NMDAR/TRPM4 interaction interface inhibitors or short ‚interface inhibitors‘) that disrupt the NMDAR/TRPM4 complex and protect against cell death in mouse models of stroke and retinal ganglion cell degeneration.[19]

Awards and honors

2001: Wolfgang-Paul Prize of the Alexander von Humboldt Foundation[20]

2016: Innovation Prize of the German BioRegions[21]

2019: Elected to the German National Academy of Science Leopoldina[22]

Notes and References

  1. Web site: Neurobiology . Heidelberg University . 2016-10-18.
  2. Web site: Interdisciplinary Center for Neurosciences (IZN) . 2016-10-18 . Heidelberg University.
  3. Web site: 2021-06-17. www.fundamentalpharma.de. Fundamental Pharma.
  4. Web site: Foundation Brainaid. 2020-10-29. www.foundationbrainaid.de.
  5. Web site: Biotechnologie.de - Menschen. Forschung. biotechnologie.de - Initiative des Bundesministeriums für Bildung und Forschung. www.biotechnologie.de. de. 2016-09-07.
  6. Bading. H.. Ginty. D. D.. Greenberg. M. E.. 1993-04-09. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science. 260. 5105. 181–186. 0036-8075. 8097060. 10.1126/science.8097060. 1993Sci...260..181B.
  7. Hagenston. Anna M.. Bading. Hilmar. 2011-11-01. Calcium signaling in synapse-to-nucleus communication. Cold Spring Harbor Perspectives in Biology. 3. 11. a004564. 10.1101/cshperspect.a004564. 1943-0264. 3220353. 21791697.
  8. Ginty. D. D.. 1997-02-01. Calcium regulation of gene expression: isn't that spatial?. Neuron. 18. 2. 183–186. 0896-6273. 9052789. 10.1016/s0896-6273(00)80258-5. 15833933. free.
  9. Hardingham. G. E.. Chawla. S.. Johnson. C. M.. Bading. H.. 1997-01-16. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature. 385. 6613. 260–265. 10.1038/385260a0. 0028-0836. 9000075. 1997Natur.385..260H. 4328815.
  10. Bading. Hilmar. 2013-09-01. Nuclear calcium signalling in the regulation of brain function. Nature Reviews. Neuroscience. 14. 9. 593–608. 10.1038/nrn3531. 1471-0048. 23942469. 14896252.
  11. Web site: Heidelberg Researchers Identify Neuron Survival Programmes - University of Heidelberg. www.uni-heidelberg.de. 2016-09-07.
  12. Web site: Mediaserver – Universität Heidelberg: Audio. archiv.ub.uni-heidelberg.de. 2016-09-07.
  13. Milnerwood. Austen J.. Gladding. Clare M.. Pouladi. Mahmoud A.. Kaufman. Alexandra M.. Hines. Rochelle M.. Boyd. Jamie D.. Ko. Rebecca W.Y.. Vasuta. Oana C.. Graham. Rona K.. 2010-01-28. Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice. Neuron. 65. 2. 178–190. 10.1016/j.neuron.2010.01.008. 1097-4199. 20152125. 12987037. free.
  14. Talantova. Maria. Sanz-Blasco. Sara. Zhang. Xiaofei. Xia. Peng. Akhtar. Mohd Waseem. Okamoto. Shu-ichi. Dziewczapolski. Gustavo. Nakamura. Tomohiro. Cao. Gang. 2013-07-02. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110. 27. E2518–2527. 10.1073/pnas.1306832110. 1091-6490. 3704025. 23776240. 2013PNAS..110E2518T. free.
  15. Web site: Proteins Produced by Activated Neurons Could Protect Against Neurodegeneration. 2015-08-24. en-US. 2016-09-07.
  16. Okamoto. Shu-ichi. Pouladi. Mahmoud A.. Talantova. Maria. Yao. Dongdong. Xia. Peng. Ehrnhoefer. Dagmar E.. Zaidi. Rameez. Clemente. Arjay. Kaul. Marcus. 2009-12-01. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nature Medicine. 15. 12. 1407–1413. 10.1038/nm.2056. 1546-170X. 2789858. 19915593.
  17. Hardingham. Giles E.. Bading. Hilmar. 2010-10-01. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nature Reviews. Neuroscience. 11. 10. 682–696. 10.1038/nrn2911. 1471-0048. 2948541. 20842175.
  18. Parsons. Matthew P.. Raymond. Lynn A.. Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders. Neuron. 82. 2. 279–293. 10.1016/j.neuron.2014.03.030. 24742457. 2014. free.
  19. Yan. Jing. Bengtson. C. Peter. Buchthal. Bettina. Hagenston. Anna M.. Bading. Hilmar. 9 October 2020. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 370. 6513. eaay3302. 10.1126/science.aay3302. 1095-9203. 33033186. 222210921.
  20. Web site: The Wolfgang Paul Award . Alexander von Humboldt Foundation . 2016-10-18.
  21. Nasenspray gegen Nervenleiden, Organmodelle statt Tierversuche, Viren gegen Krebs: Innovationspreis der BioRegionen . Nasal spray against nervous disorders, organ models instead of animal testing, virus against cancer: Innovation Award BioRegions . de . Bio Deutschland . 2016-10-18.
  22. Web site: List of Members. 2020-10-29. Nationale Akademie der Wissenschaften Leopoldina. en.

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