Highwire (protein) explained

Highwire (Hiw) is an E3 ubiquitin ligase protein associated with neuromuscular junction growth.^[1] It is frequently studied in Drosophila melanogaster. Its known orthologs are PAM, RPM-1, and PHR-1.

References

• Wan HI, DiAntonio A, Fetter RD, Bergstrom K, Strauss R, Goodman CS . Highwire regulates synaptic growth in Drosophila . Neuron . 26 . 2 . 313–29 . May 2000 . 10839352 . 10.1016/S0896-6273(00)81166-6. free .
• Wang H . Characterization of zebrafish Esrom (Myc-binding protein 2) RCC1-like domain splice variants . Mol Cell Biochem . 339. 1–2. 191–199. February 2010 . 20143133 . 10.1007/s11010-010-0385-x . 10637013 .

Notes and References

1. Bloom, Joseph A. . Bradley R. Miller . Joshua R. Sanes . Aaron DiAntonio . The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons . Genes & Development . 2593–2606 . September 2007 . 17901218 . 10.1101/gad.1592107. 21 . 20 . 2000324.