| Country: | ISR |
| Type: | Hwy |
| Image Notes: | Tel Arad and Highway 80 |
| Route: | 80 |
| Length Km: | 34 |
| Direction A: | South |
| Terminus A: | Ar'ara BaNegev Junction |
| Direction B: | North |
| Terminus B: | Amasa Junction |
| Previous Route: | 79 |
| Previous Type: | Hwy |
| Next Route: | 85 |
| Next Type: | Hwy |
Highway 80 is a north-south highway in southern Israel, east of Beersheba. It connects Ar'arat an-Naqab in the south to Metzadot Yehuda in the north. It is long.