| Country: | ISR |
| Type: | Highway |
| Route: | 66 |
| Length Km: | 18 |
| Established: | 1929 |
| Direction A: | South |
| Terminus A: | Salem Security Checkpoint |
| Direction B: | North |
| Terminus B: | Tel Kashish Interchange |
| Map Notes: | Tel Megiddo National Park and Highway 66 |
| Previous Route: | 65 |
| Previous Type: | Hwy |
| Next Route: | 67 |
| Next Type: | Hwy |
Highway 66 (Hebrew: כביש 66) is a north–south highway in the Jezreel Valley in northern Israel.
Highway 66 extends along the eastern lowlands below the Menashe Heights and the Carmel. It is long. In the past the road continued south to Jenin, but today it ends at checkpoint. The northern section of the highway was constructed in 1929 to allow access to Tel Megiddo archaeological site for the anticipated visit of John D. Rockefeller Jr. The southern section was constructed in the 1930s, and the highway opened to general traffic between Haifa and Jenin in 1936 as a bypass road avoiding Nazareth.