| State: | AR |
| Type: | AR |
| Route: | 395 |
| Maint: | AHTD |
| Map Custom: | yes |
| Section1: | Southern segment |
| Length Mi1: | 3.00 |
| Length Ref1: | [1] |
| Direction A: | South |
| Direction B: | North |
| Terminus A1: | Byron Road south of Salem |
| Terminus B1: | in Salem |
| Section2: | Northern segment |
| Length Mi2: | 10.43 |
| Terminus A2: | in Salem |
| Terminus B2: | northeast of Moko |
| Counties: | Fulton |
| Previous Type: | AR |
| Previous Route: | 394 |
| Next Type: | AR |
| Next Route: | 396 |
Arkansas Highway 395 (AR 395) is a state highway made up of two sections, both of which are in Fulton County. The southern segment is a 3adj=midNaNadj=mid spur route that begins southwest of Salem and ends at U.S. Route 62 (US 62) / US 412 in Salem. The northern segment begins on the northeastern side of Salem at Highway 9 and travels north and east to the Missouri state line, where it becomes Missouri Route 17.
Highway 395 begins at a begin/end state maintenance sign southwest of Salem; the highway continues southwest as Byron Road. From its beginning, the route heads to the northeast towards Salem, along the winding Byron Road. On the southwestern side of Salem, the highway ends at U.S. 62 / U.S. 412.[2]
Highway 395 reemerges on the northeast side of Salem near the Fulton County Hospital at an intersection with Highway 9. From Salem it heads north, roughly parallel to the south fork of the Spring River. It passes through a mix of grassland and forest, with a few houses dotted along the way. At the small community of Moko, Highway 395 briefly turns to the east before curving back to the north. At the Missouri state line, the designation ends, but the highway continues as Missouri Route 17.