High affinity cationic amino acid transporter 1 explained

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.^{[1] [2]}

See also

• Solute carrier family

Further reading

• Yoshimoto T, Yoshimoto E, Meruelo D . Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor . Virology . 185 . 1 . 10–7 . November 1991 . 1718082 . 10.1016/0042-6822(91)90748-Z . free .
• Kamath SG, Furesz TC, Way BA, Smith CH . Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1 . The Journal of Membrane Biology . 171 . 1 . 55–62 . September 1999 . 10485994 . 10.1007/s002329900558 . 25084494 .
• Hammermann R, Brunn G, Racké K . Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4 . Amino Acids . 21 . 2 . 211–9 . 2002 . 11665818 . 10.1007/s007260170029 . 30892800 .
• Cariappa R, Heath-Monnig E, Furesz TC, Kamath SG, Smith CH . Stable polarized expression of hCAT-1 in an epithelial cell line . The Journal of Membrane Biology . 186 . 1 . 23–30 . March 2002 . 11891586 . 10.1007/s00232-001-0133-y . 25743745 .
• Furesz TC, Heath-Monnig E, Kamath SG, Smith CH . Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes . The Journal of Membrane Biology . 189 . 1 . 27–33 . September 2002 . 12202949 . 10.1007/s00232-002-1001-0 . 24776183 .
• Kizhatil K, Albritton LM . System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells . American Journal of Physiology. Cell Physiology . 283 . 6 . C1784-94 . December 2002 . 12388095 . 10.1152/ajpcell.00061.2002 . 17848190 .
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . December 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Schnorr O, Suschek CV, Kolb-Bachofen V . The importance of cationic amino acid transporter expression in human skin . The Journal of Investigative Dermatology . 120 . 6 . 1016–22 . June 2003 . 12787129 . 10.1046/j.1523-1747.2003.12139.x . free .
• González M, Flores C, Pearson JD, Casanello P, Sobrevia L . Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells . Pflügers Archiv . 448 . 4 . 383–94 . July 2004 . 15064952 . 10.1007/s00424-004-1261-x . 25238852 .
• Schwartz IF, Iaina A, Benedict Y, Wollman Y, Chernichovski T, Brasowski E, Misonzhnik F, Ben-Dor A, Blum M, Levo Y, Schwartz D . Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats . Kidney International . 65 . 4 . 1311–9 . April 2004 . 15086470 . 10.1111/j.1523-1755.2004.00508.x . free .
• Rotmann A, Strand D, Martiné U, Closs EI . Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity . The Journal of Biological Chemistry . 279 . 52 . 54185–92 . December 2004 . 15491978 . 10.1074/jbc.M409556200 . free .
• Cui Z, Tuladhar R, Hart SL, Marber MS, Pearson JD, Baydoun AR . Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells . Nitric Oxide . 12 . 1 . 21–30 . February 2005 . 15631944 . 10.1016/j.niox.2004.11.001 . 2299/1712 . free .
• Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM . Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction . Circulation . 115 . 10 . 1269–74 . March 2007 . 17325243 . 10.1161/CIRCULATIONAHA.106.665836 . free .
• Kaneko S, Okuda-Ashitaka E, Ando A, Nishimura K, Igarashi K, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S . Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells . American Journal of Physiology. Cell Physiology . 293 . 2 . C729-37 . August 2007 . 17494634 . 10.1152/ajpcell.00018.2007 . 9039432 .

Notes and References

1. Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM . The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14 . Genomics . 12 . 3 . 430–4 . March 1992 . 1348489 . 10.1016/0888-7543(92)90431-Q .
2. Web site: Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1.