The High Priest of Osiris served at Abydos.
Some high priests were:
| High Priest | Reign | Dynasty ! | Comments | ||
|---|---|---|---|---|---|
| Nebwawy | Thutmose III | 18th Dynasty | |||
| Heqanefer | Thutmose III, Amenhotep II | 18th Dynasty | |||
| To[1] | Horemheb, Ramesses I | 18th Dynasty | |||
| Hat | Ramesses I, Seti I | 19th Dynasty | Possibly brother-in-law of To | ||
| Mery | Seti I, Ramesses II | 19th Dynasty | Son of the High Priest of Osiris Hat and his wife Iuy. Mery's wife Maianuy was the daughter of the High Priest of Osiris, To, justified, born of Buia. | ||
| Wenennefer | Ramesses II | 19th Dynasty | Son of the High Priest of Osiris Mery and his wife Maianuy. | ||
| Hori | Ramesses II | 19th Dynasty | Son of the High Priest of Osiris Wenennefer and his wife Tiy. | ||
| Yuyu | Ramesses II, Merneptah? | 19th Dynasty | Son of the High Priest of Osiris Wenennefer and his wife Tiy. Brother of Hori. | ||
| Siese | Merneptah | 19th Dynasty | Son of the High Priest of Osiris Yuyu | ||
| Hori II | Ramesses III | 20th Dynasty |