Tradename: | Cysview, Hexvix |
Dailymedid: | Hexaminolevulinate |
Atc Prefix: | V04 |
Atc Suffix: | CX06 |
Legal Au: | S4 |
Legal Au Comment: | [1] |
Legal Ca: | Rx-only |
Legal Us: | Rx-only |
Legal Us Comment: | [2] |
Cas Number: | 140898-97-1 |
Pubchem: | 6433083 |
Drugbank: | DB06261 |
Chemspiderid: | 4938272 |
Unii: | G7H20TKI67 |
Kegg: | D04436 |
Chebi: | 134892 |
Chembl: | 1201784 |
Hexaminolevulinate, sold under the brand name Cysview among others, is an imaging agent that lights up under blue light during a blue light cystoscopy. It is used to help detect non-muscle invasive bladder cancer (NMIBC), in particular papillary tumors and carcinoma in situ (CIS).
It made by Photocure ASA, a Norwegian pharmaceutical company.
Hexaminolevulinate is a structural analogue to 5-aminolevulinic acid (a precursor to the porphyrin ring of heme), and is internalized and processed into the photoactive protoporphyrin IX at a high rate by tumor cells. After exposure to 360-450 nm light, the porphyrin will fluoresce red.https://pubchem.ncbi.nlm.nih.gov/compound/Hexaminolevulinate#section=Metabolism-Metabolites