Hexahydrocannabivarin Explained

Hexahydrocannabivarin (HHCV, HHC-V) is a semi-synthetic cannabinoid derivative, the hydrogenated derivative of tetrahydrocannabivarin (THCV). It was first synthesised by Roger Adams in 1942 and produces only weak cannabinoid-like effects in animals.^[1] More recently it has been sold as an ingredient in grey-market cannabinoid products. It has been investigated for potential antineoplastic activity in vitro.^{[2] [3]}

See also

• Hexahydrocannabinol
• Hexahydrocannabutol
• Hexahydrocannabihexol
• Hexahydrocannabiphorol

Notes and References

1. Adams R, Loewe S, Smith CM, McPhee WD . Tetrahydrocannabinol homologs and analogs with marihuana activity. XIII. . Journal of the American Chemical Society . March 1942 . 64 . 3 . 694–697 . 10.1021/ja01255a061 .
2. Tesfatsion T, Collins A, Ramirez G, Mzannar Y, Khan H, Aboukameel O, Azmi A, Jagtap P, Ray K, Cruces W . Antineoplastic Properties of THCV, HHC, HHCV and their anti-Proliferative effects on HPAF-II, MIA-paca2, Aspc-1, and PANC-1 PDAC Pancreatic Cell Lines. . ChemRxiv . 2022 . 10.26434/chemrxiv-2022-v4zqc .
3. Docampo-Palacios ML, Ramirez GA, Tesfatsion TT, Okhovat A, Pittiglio M, Ray KP, Cruces W . Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs . Molecules (Basel, Switzerland) . 28 . 17 . September 2023 . 6434 . 37687263 . 10.3390/molecules28176434 . 10490552 . free .