Hexacyclonate Explained

Verifiedrevid:	447989906
Iupac Name:	[1-(hydroxymethyl)cyclohexyl]acetic acid
Width:	200
Cas Number:	7491-42-1
Pubchem:	23444
Chemspiderid:	21921
Chembl:	2110826
Unii:	2K0FP9UB6A
C:	9
H:	16
O:	3
Smiles:	O=C(O)CC1(CO)CCCCC1
Stdinchi:	1S/C9H16O3/c10-7-9(6-8(11)12)4-2-1-3-5-9/h10H,1-7H2,(H,11,12)
Stdinchikey:	WMJPAYUKEVEBCN-UHFFFAOYSA-N

Hexacyclonate (Gevilon) is a stimulant drug. It has been used for the treatment of alcoholism^[1] and for increasing motivation in elderly patients,^[2] but Gevilon (containing a different active substance - gemfibrozil) is now mainly used for the treatment of hyperlipoproteinaemia.^{[3] [4]} It is chemically similar to the anticonvulsant gabapentin, with a hydroxyl group replacing the amine.

The latter use may be incorrectly assigned, as "Gevilon" has been used as a trade name for gemfibrozil, a well-known drug for dislypidemia.

Notes and References

1. Chesrow EJ, Sabatini R, Musci JP, Kaplitz SE, Marquardt GH . Adjunctive treatment of the chronic alcoholic with hexacyclonate sodium . The Illinois Medical Journal . 121 . 546–8 . May 1962 . 13878809 .
2. Morrison BO . Pharmaco-motivation of the geriatric patient: a preliminary report on hexacyclonate . The Journal of the Louisiana State Medical Society . 114 . 23–6 . January 1962 . 14476295 .
3. Milewicz A, Plamieniak Z, Bohdanowicz-Pawlak A . Therapeutic effect of gevilon in patients with hyperlipoproteinaemia . Materia Medica Polona. Polish Journal of Medicine and Pharmacy . 24 . 2 . 91–5 . 1992 . 1307777 .
4. Gazdikova K, Korecka P, Springer V, Gazdik F . Pharmacoeconomic aspects of patients treated by hemodialysis . Bratislavske Lekarske Listy . 104 . 10 . 329–34 . 2003 . 15055734 .