| Official Name: | Hermisende |
| Subdivision Name3: | Hermisende |
| Area Total Km2: | 109 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
| Website: | www.hermisende.com |
Hermisende is a municipality located in the province of Zamora, Castile and León, Spain. According to the 2004 census (INE), the municipality has a population of 383 inhabitants.It was ceded by Portugal after the Portuguese Restoration War in the Treaty of Lisbon (1668).