| Hermann von Thile | |
| Order: | State Secretary for Foreign Affairs |
| Term Start: | 21 March 1871 |
| Term End: | 30 September 1872 |
| Chancellor: | Otto von Bismarck |
| Predecessor: | Position established |
| Successor: | Hermann Ludwig von Balan |
| Birth Date: | 19 December 1812 |
| Birth Place: | Berlin, Kingdom of Prussia |
| Death Place: | Berlin, German Empire |
| Occupation: | Diplomat |
Karl Hermann von Thile (19 December 1812 – 26 December 1889) was a German diplomat, and the first Foreign Secretary of Germany and head of the Foreign Office (21 March 1871 – 30 September 1872).
He became a diplomat in the Kingdom of Prussia in 1837, and was sent to Rome, Bern, Vienna and London, before he was appointed as the Envoy to Rome in 1854, succeeding Christian Karl Josias von Bunsen. In 1862 he became Under-Secretary of State in the Prussian Ministry of Foreign Affairs.
As Secretary of State, he wielded less power over the direction of the foreign policy than Chancellor Otto von Bismarck.