Hepsin Explained
| Hepsin |
| Ec Number: | 3.4.21.106 |
| Cas Number: | 112398-23-9 |
Hepsin is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
This type-II membrane-associated serine peptidase plays a role in cell growth and development.
See also
Notes and References
- Zhukov A, Hellman U, Ingelman-Sundberg M . Purification and characterization of hepsin from rat liver microsomes . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 1337 . 1 . 85–95 . January 1997 . 9003440 . 10.1016/s0167-4838(96)00152-5 .
- Kazama Y, Hamamoto T, Foster DC, Kisiel W . Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation . The Journal of Biological Chemistry . 270 . 1 . 66–72 . January 1995 . 7814421 . 10.1074/jbc.270.1.66 . free .
- Torres-Rosado A, O'Shea KS, Tsuji A, Chou SH, Kurachi K . Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth . Proceedings of the National Academy of Sciences of the United States of America . 90 . 15 . 7181–5 . August 1993 . 8346233 . 47100 . 10.1073/pnas.90.15.7181 . 1993PNAS...90.7181T . free .
