MST1 explained

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.^{[1] [2] [3]}

Further reading

• Han S, Stuart LA, Degen SJ . Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. . Biochemistry . 30 . 40 . 9768–80 . 1991 . 1655021 . 10.1021/bi00104a029 .
• Skeel A, Yoshimura T, Showalter SD, etal . Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. . J. Exp. Med. . 173 . 5 . 1227–34 . 1991 . 1827141 . 10.1084/jem.173.5.1227 . 2118857 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Waltz SE, Gould FK, Air EL, etal . Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein . J. Biol. Chem. . 271 . 15 . 9024–32 . 1996 . 8621550 . 10.1074/jbc.271.15.9024 . free .
• Creasy CL, Ambrose DM, Chernoff J . The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain . J. Biol. Chem. . 271 . 35 . 21049–53 . 1996 . 8702870 . 10.1074/jbc.271.35.21049 . free .
• Sakamoto O, Iwama A, Amitani R, etal . Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility . J. Clin. Invest. . 99 . 4 . 701–9 . 1997 . 9045873 . 10.1172/JCI119214 . 507853 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Yoshikawa W, Hara H, Takehara T, etal . Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein . Arch. Biochem. Biophys. . 363 . 2 . 356–60 . 1999 . 10068459 . 10.1006/abbi.1998.1090 .
• Degen SJ, McDowell SA, Waltz SE, etal . Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein . DNA Seq. . 8 . 6 . 409–13 . 2000 . 10728827 . 10.3109/10425179809020903 .
• Skeel A, Leonard EJ . alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein . J. Biol. Chem. . 276 . 24 . 21932–7 . 2001 . 11274154 . 10.1074/jbc.M100652200 . free .
• Rampino T, Collesi C, Gregorini M, etal . Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells . J. Am. Soc. Nephrol. . 13 . 3 . 649–57 . 2002 . 10.1681/ASN.V133649 . 11856768 . free .
• Zhou YQ, Chen YQ, Fisher JH, Wang MH . Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages . J. Biol. Chem. . 277 . 41 . 38104–10 . 2002 . 12177064 . 10.1074/jbc.M206167200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Santoro MM, Gaudino G, Marchisio PC . The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration . Dev. Cell . 5 . 2 . 257–71 . 2003 . 12919677 . 10.1016/S1534-5807(03)00201-6 . free .
• Angeloni D, Danilkovitch-Miagkova A, Miagkov A, etal . The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation . J. Biol. Chem. . 279 . 5 . 3726–32 . 2004 . 14597639 . 10.1074/jbc.M309342200 . free .
• Matsuzaki S, Canis M, Pouly JL, etal . The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis . Mol. Hum. Reprod. . 11 . 5 . 345–9 . 2005 . 15764806 . 10.1093/molehr/gah162 . free .
• Zalcenstein A, Weisz L, Stambolsky P, etal . Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53 . Oncogene . 25 . 3 . 359–69 . 2006 . 16170349 . 10.1038/sj.onc.1209061 . free .
• Liu T, Qian WJ, Gritsenko MA, etal . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .

Notes and References

1. Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI . Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel . Am J Hum Genet . 43 . 4 . 442–51 . Oct 1988 . 2902784 . 1715492 .
2. Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ . Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3 . J Biol Chem . 268 . 21 . 15461–8 . Aug 1993 . 10.1016/S0021-9258(18)82279-7 . 8393443 . free .
3. Web site: Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like).