Hepatitis C virus cis-acting replication element explained

Hepatitis C virus (HCV) cis-acting replication element (CRE)
Symbol:	HepC_CRE
Rfam:	RF00260
Rna Type:	Cis-reg
Tax Domain:	Viruses

The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.^[1]

See also

• Hepatitis C alternative reading frame stem-loop
• Hepatitis C virus 3'X element
• Hepatitis C virus stem-loop VII
• Hepatitis C stem-loop IV
• Hepatitis C

Notes and References

1. You S, Stump DD, Branch AD, Rice CM . A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication . Journal of Virology . 78 . 3 . 1352–1366 . February 2004 . 14722290 . 321395 . 10.1128/JVI.78.3.1352-1366.2004 .