Hepatitis B virus PRE beta explained

Hepatitis B virus PRE beta
Symbol:	HBV_PREbeta
Rfam:	HBV_PREbeta
Rna Type:	Cis-reg;

The Hepatitis B virus PRE stem-loop beta (HBV PRE SL-beta) is an RNA structure that is shown to play a role in nuclear export of HBV mRNAs.

The minimal HBV PREbeta structure consists of a 23 nt stem-loop, with a 9 nt apical loop. The conserved stem-loop was predicted within the HBV PRE sequence and confirmed by mutagenesis.^{[1] [2]}

See also

• Hepatitis B virus PRE alpha
• HBV RNA encapsidation signal epsilon
• Hepatitis B virus PRE 1151–1410

Notes and References

1. 10.1093/nar/26.21.4818. Smith Gj. 3rd. Donello. JE. Lück. R. Steger. G. Hope. TJ. The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function. Nucleic Acids Research. 26. 21. 4818–4827. 1998 . 9776740. 147918.
2. Chen. A. Panjaworayan T-Thienprasert. N. Brown. CM. Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus.. World Journal of Gastroenterology. 7 July 2014. 20. 25. 7993–8004. 25009369. 10.3748/wjg.v20.i25.7993. 4081668. free.