Heparosan-N-sulfate-glucuronate 5-epimerase explained

Heparosan-N-sulfate-glucuronate 5-epimerase
Ec Number:	5.1.3.17
Cas Number:	112567-86-9
Width:	270

Heparosan-N-sulfate-glucuronate 5-epimerase (heparosan epimerase, heparosan-N-sulfate-D-glucuronosyl 5-epimerase, C-5 uronosyl epimerase, polyglucuronate epimerase, D-glucuronyl C-5 epimerase, poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase) is an enzyme with systematic name poly((1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase.^[1] This enzyme catalyses the following chemical reaction

heparosan-N-sulfate D-glucuronate

\rightleftharpoons heparosan-N-sulfate L-iduronate

This enzyme acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine units in the heparin precursor.

See also

• heparan sulfate

Notes and References

1. Bäckström G, Höök M, Lindahl U, Feingold DS, Malmström A, Rodén L, Jacobsson I . Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase . The Journal of Biological Chemistry . 254 . 8 . 2975–82 . April 1979 . 10.1016/S0021-9258(17)30171-0 . 107165 . free .