| Henry William Worley | |
| Office: | 41st Mayor of Columbus |
| Birth Date: | 9 April 1877 |
| Birth Place: | London, England |
| Term Start: | 1932 |
| Term End: | 1935 |
| Predecessor: | James J. Thomas |
| Successor: | Myron B. Gessaman |
| Party: | Democratic |
Henry William Worley (April 9, 1877 – August 5, 1938) was the 41st mayor of Columbus, Ohio and the 37th person to serve in that office. He was elected in 1931 and served Columbus during the rise of the New Deal programs during the presidency of Franklin Delano Roosevelt. After one term in office he was defeated in the 1935 mayoral election by Myron B. Gessaman.