Henry Rzepa Explained

Henry Rzepa
Birth Name:Henry Stephen Rzepa
Birth Date:[1]
Fields:Chemistry
Alma Mater:Imperial College London (PhD)
Thesis Title:Hydrogen Transfer Reactions of Indoles
Thesis Url:http://hdl.handle.net/10044/1/20860
Thesis Year:1974
Awards:Herman Skolnik Award (2012)

Henry Stephen Rzepa (born 1950)[1] is a chemist and Emeritus Professor of Computational Chemistry at Imperial College London.[2] [3] [4]

Education

Rzepa was born in 1950 and was educated at Wandsworth Comprehensive School in London. He then entered the chemistry department at Imperial College London where he graduated in 1971. He stayed to do a Ph.D. on the physical organic chemistry of indoles supervised by Brian Challis.[5] [6]

Career and research

After spending three years doing postdoctoral research at the University of Texas at Austin, Texas with Michael Dewar[7] in the then emerging field of computational chemistry, he returned to Imperial College and was eventually appointed as Professor of the college in 2003. he is Emeritus Professor of Computational Chemistry.[8] [9]

His research interests directed towards combining different types of chemical information tools for solving structural, mechanistic and stereochemical problems in organic, bioorganic, organometallic chemistry and catalysis, using techniques such as semiempirical molecular orbital methods (the MNDO family), Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography and ab initio quantum theories. Aware of the complex semantic issues involved in converging different areas of chemistry to address modern multidisciplinary problems, he started investigating the use of the Internet as an information and integrating medium around 1987, focusing in 1994 on the World Wide Web as having the most potential.[10] Peter Murray-Rust and he first introduced Chemical Markup Language (CML) in 1995 as a rich carrier of semantic chemical information and data; and they coined the term Datument as a portmanteau word to better express the evolution from the documents produced by traditional academic publishing methods to the Semantic Web ideals expressed by Tim Berners-Lee.[11] [12] [13]

His contributions to chemistry[14] [15] [16] [17] [18] [19] [20] include exploration of Möbius aromaticity, highlighted by the theoretical discovery of relatively stable forms of cyclic conjugated molecules which exhibit two and higher half-twists in the topology rather than just the single twist associated with Mobius systems (and hence possibly better termed Johann Benedict Listing rings). He is responsible for unraveling the mechanistic origins of stereocontrol in a variety of catalytic polymerisation reactions, including that of lactide to polylactide, a new generation of bio-sustainable polymer not dependent on oil. He is also known for the integration of chemistry (in the form of CML) with emergent Internet technologies and trends such as RSS and podcasting, for the introduction of the Chemical MIME types in 1994, and for organizing the ECTOC online conferences in organic chemistry, which ran from 1995-1998.[21]

Awards and honours

Rzepa was awarded the Herman Skolnik Award in 2012 by the American Chemical Society.[22]

Notes and References

  1. Web site: https://web.archive.org/web/20170425104833/https://beta.companieshouse.gov.uk/officers/Rb-Spj4_WlYGstiIDb_waJg3amQ/appointments. 2017-04-25. Henry Stephen RZEPA, June 1950. companieshouse.gov.uk. Companies House. London. Anon. 2017. dead.
  2. Web site: A Royal Society of Chemistry interview with Henry Rzepa . dead . https://web.archive.org/web/20121019053740/http://www.rsc.org/Publishing/ChemScience/Volume/2009/05/Henry_Rzepa_interview.asp . 2012-10-19 .
  3. Allan . C. S. M. . Rzepa . H. S. . 10.1039/b810147g . A computational investigation of the structure of polythiocyanogen . . 48 . 6925–6932 . 2008 . 19050778.
  4. Rzepa . H. S. . Wormholes in chemical space connecting torus knot and torus link π-electron density topologies . 10.1039/b810301a . . 11 . 9 . 1340–1345 . 2009 . 19224034. 2009PCCP...11.1340R .
  5. PhD. University of London. Hydrogen transfer reactions of indoles. Henry Stephen. Rzepa. 1974. ethos.bl.uk. 930651784. 10044/1/20860. 10.5281/zenodo.18777.
  6. Challis. Brian C.. Rzepa. Henry S.. Heteroaromatic hydrogen exchange reactions. Part VIII. The ionisation of 1,3-dimethylindolin-2-one. Journal of the Chemical Society, Perkin Transactions 2. 15. 1975. 1822. 0300-9580. 10.1039/p29750001822. 10044/1/21275.
  7. Dewar. M. J. S.. Michael J. S. Dewar. Mckee. M. L.. Rzepa. H. S.. ChemInform Abstract: MNDO Parameters for third period elements. Chemischer Informationsdienst. 9. 34. 1978. 0009-2975. 10.1002/chin.197834001.
  8. Web site: Information on conference speakers. ukoln.ac.uk.
  9. Web site: Rzepa Biography. rzepa.net.
  10. Rzepa. Henry S.. Whitaker. Benjamin J.. Winter. Mark J.. Chemical applications of the World-Wide-Web system. Journal of the Chemical Society, Chemical Communications. 17. 1994. 1907. 0022-4936. 10.1039/c39940001907. 95897719.
  11. http://pubs.acs.org/4librarians/livewire/2008/9.3/news1.html ACS Publications News
  12. , Imperial College London
  13. , Science & Engineering South
  14. O'Boyle . N. M. . Guha . R. . Willighagen . E. L. . Adams . S. E. . Alvarsson . J. . Bradley . J. C. . Filippov . I. V. . Hanson . R. M. . Hanwell . M. D. . Hutchison . 10.1186/1758-2946-3-37 . G. R. . James . C. A. . Jeliazkova . N. . Lang . A. S. D. . Langner . K. M. . Lonie . D. C. . Lowe . D. M. . Pansanel . J. R. M. . Pavlov . D. . Spjuth . O. . Steinbeck . C. . Tenderholt . A. L. . Theisen . K. J. . Murray-Rust . P. . Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on . Journal of Cheminformatics. 3 . 1 . 37 . 2011 . 21999342. 3205042 . free .
  15. Guha . R. . Howard . M. T. . Hutchison . G. R. . Murray-Rust . P. . Peter Murray-Rust. Rzepa . H. . Henry Rzepa. Steinbeck . C. . Christoph Steinbeck. Wegner . J. . Willighagen . E. L. . 10.1021/ci050400b . The Blue Obelisk - Interoperability in Chemical Informatics . Journal of Chemical Information and Modeling. 46 . 3 . 991–998 . 2006 . 16711717. 4878861.
  16. Rzepa . H. S. . A Double-Twist Möbius-Aromatic Conformation of [14]Annulene . 10.1021/ol0518333 . . 7 . 21 . 4637–4639 . 2005 . 16209498.
  17. 16633661. 2006. Fowler. P. W.. Aromaticity rules for cycles with arbitrary numbers of half-twists. Physical Chemistry Chemical Physics. 8. 15. 1775–7. Rzepa. H. S.. 10.1039/b601655c. 2006PCCP....8.1775F.
  18. 15839705. 2005. Marshall. E. L.. A computational analysis of the ring-opening polymerization of rac-lactide initiated by single-site beta-diketiminate metal complexes: Defining the mechanistic pathway and the origin of stereocontrol. Journal of the American Chemical Society. 127. 16. 6048–51. Gibson. V. C.. Rzepa. H. S.. 10.1021/ja043819b.
  19. 15032525. 2004. Murray-Rust. P. Chemical markup, XML, and the World Wide Web. 5. Applications of chemical metadata in RSS aggregators. Journal of Chemical Information and Modeling. 44. 2. 462–9. Rzepa. H. S.. Williamson. M. J.. Willighagen. E. L.. 10.1021/ci034244p. 10.1.1.477.524.
  20. H. S. Rzepa and M. E. Cass . Progress towards a Holistic Web: Integrating OpenSource programs, Semantic data, Wikis and Podcasts . http://www.stolaf.edu/depts/chemistry/bh/confchem/confchem_s2006.htm . Spring ConfChem . May–June 2006.
  21. Web site: Rzepa . Henry S. . 1998-03-13 . Electronic Conferences on Trends in Organic Chemistry . 2024-01-15 . www.ch.ic.ac.uk . English.
  22. Web site: Anon. 2011. CCL Archives. ccl.net.

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