| Bridge Name: | Henderson Bridge |
| Carries: | CSX Transportation railroad |
| Crosses: | Ohio River |
| Locale: | Henderson, Kentucky and Vanderburgh County, Indiana |
| Design: | Truss bridge |
| Mainspan: | 648sigfig=3NaNsigfig=3 |
| Length: | 121230NaN0 |
| Open: | December 31, 1932 |
| Coordinates: | 37.8456°N -87.5964°W |
The Henderson Bridge is a railroad bridge spanning the Ohio River between Henderson, Kentucky and Vanderburgh County, Indiana. The bridge is owned by the CSX Transportation.
The original bridge was constructed in 1884 to 1885 by the Louisville and Nashville Railroad at a cost of $2,000,000. The single-tracked bridge was approximately long, and its longest span, at, was reputed to be the longest trestle span in the world at that time. The bridge ran from the northern edge of Main Street in Henderson to the low water mark on the Indiana side, resting on 15 stone piers. It was designed to carry two 118000lb engines followed by 60000lb coal tenders, and its maximum uniform load capacity was . A crowd of 8,000 watched the first train cross the bridge on July 13, 1885.
Prior to the opening of the bridge, railroad passengers and freight had to be transferred to a ferry for the river crossing. The bridge reduced the travel time by several hours.
By 1930 the volume and weight of train traffic were taxing the capabilities of the original bridge. Construction of a new bridge just upstream of the old one began in May 1931. The new bridge, costing over $3,000,000, opened on December 31, 1932. Including its approaches, It is long, and its span over the main channel is long. The demolition of the old bridge, using dynamite, was completed on December 11, 1933.