Heme ligase explained

Heme ligase
Ec Number:	4.99.1.8

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe³⁺:ferriprotoporphyrin IX ligase (β-hematin-forming).^[1] This enzyme catalyses the following reaction:

2 ferriprotoporphyrin IX

\rightleftharpoons beta-hematin

This heme detoxifying enzyme is found in Plasmodium parasites.

Notes and References

1. Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D . HDP-a novel heme detoxification protein from the malaria parasite . PLOS Pathogens . 4 . 4 . e1000053 . April 2008 . 18437218 . 2291572 . 10.1371/journal.ppat.1000053 . free .