| Post: | Prime Minister |
| Body: | the Democratic Republic of São Tomé and Príncipe |
| Insignia: | Coat of arms of São Tomé and Príncipe.svg |
| Insigniacaption: | Coat of arms of São Tomé and Príncipe |
| Incumbent: | Patrice Trovoada |
| Incumbentsince: | 11 November 2022 |
| Type: | Head of government |
| Member Of: | Council of Ministers National Assembly |
| Appointer: | President of São Tomé and Príncipe |
| Precursor: | Governor of Portuguese São Tomé and Príncipe |
| Formation: | 12 July 1975 |
| First: | Miguel Trovoada |
| Salary: | 43,818,893 dobras annually[1] |
This article lists the prime ministers of São Tomé and Príncipe, an island country in the Gulf of Guinea off the western equatorial coast of Central Africa, since the establishment of the office of prime minister of Portuguese São Tomé and Príncipe in 1974. Leonel Mário d'Alva was the first person to hold the office, taking effect on 21 December 1974. The incumbent is Patrice Trovoada, having taken office on 11 November 2022.
| Portrait | Name | Election | Term of office | Political party | ||||
|---|---|---|---|---|---|---|---|---|
| Took office | Left office | Time in office | ||||||
| 1 | Miguel Trovoada | 1975 | 12 July 1975 | 9 April 1979 | MLSTP–PSD | |||
| Post abolished (9 April 1979 – 8 January 1988) | ||||||||
| 2 | Celestino Rocha da Costa | — | 8 January 1988 | 7 February 1991 | MLSTP–PSD | |||
| 3 | Daniel Daio | 1991 | 7 February 1991 | 16 May 1992 | PCD | |||
| 4 | Norberto Costa Alegre | — | 16 May 1992 | 2 July 1994 | PCD | |||
| 5 | Evaristo Carvalho | — | 7 July 1994 | 25 October 1994 | ADI | |||
| 6 | Carlos Graça | 1994 | 25 October 1994 | 31 December 1995 | MLSTP–PSD | |||
| 7 | Armindo Vaz d'Almeida | — | 31 December 1995 | 19 November 1996 | MLSTP–PSD | |||
| 8 | Raul Bragança Neto | — | 19 November 1996 | 5 January 1999 | MLSTP–PSD | |||
| 9 | Guilherme Posser da Costa | 1998 | 5 January 1999 | 26 September 2001 | MLSTP–PSD | |||
| Evaristo Carvalho | — | 26 September 2001 | 28 March 2002 | ADI | ||||
| 10 | Gabriel Costa | 2002 | 28 March 2002 | 7 October 2002 | ADI[2] | |||
| 11 | Maria das Neves | — | 7 October 2002 | 18 September 2004 | MLSTP–PSD | |||
| 12 | Damião Vaz d'Almeida | — | 18 September 2004 | 8 June 2005 | MLSTP–PSD | |||
| 13 | Maria do Carmo Silveira | — | 8 June 2005 | 21 April 2006 | MLSTP–PSD | |||
| 14 | Tomé Vera Cruz | 2006 | 21 April 2006 | 14 February 2008 | MDFM–PL | |||
| 15 | Patrice Trovoada | — | 14 February 2008 | 22 June 2008 | ADI | |||
| 16 | Joaquim Rafael Branco | — | 22 June 2008 | 14 August 2010 | MLSTP–PSD | |||
| Patrice Trovoada | 2010 | 14 August 2010 | 12 December 2012 | ADI | ||||
| Gabriel Costa | — | 12 December 2012 | 25 December 2014 | UDD[3] | ||||
| Patrice Trovoada | 2014 | 25 December 2014 | 3 December 2018 | ADI | ||||
| 17 | Jorge Bom Jesus | 2018 | 3 December 2018 | 10 November 2022 | MLSTP–PSD | |||
| Patrice Trovoada | 2022 | 11 November 2022 | Incumbent | ADI | ||||