| Mambéré-Kadéi | |
| Settlement Type: | Prefecture |
| Mapsize: | 200px |
| Image Map1: | Mambere-Kadei sub-prefectures.png |
| Map Caption1: | Sub-prefectures of Mambéré-Kadéi |
| Subdivision Type: | Country |
| Subdivision Name: | Central African Republic |
| Seat Type: | Capital |
| Seat: | Berbérati |
| Coordinates: | 4.5°N 16°W |
| Leader Title: | Prefect |
| Leader Name: | Theodore Papillon Malengue[1] |
| Area Total Km2: | 30203 |
| Population Total: | 197535 |
| Population As Of: | 2003 census |
| Population Density Km2: | auto |
Mambéré-Kadéï in French pronounced as /mɑ̃.be.ʁe ka.de.i/ is one of the 20 prefectures of the Central African Republic. The prefecture covers 30,203 km2 and had a population of 197,535 as of the 2003 census, giving a population density of 6.5 inhabitants/km2. Its capital is Berbérati. It is named for the Mambéré River and Kadéï River.
Until 1992, it was known as Haute-Sangha.