Haplogroup JT explained

JT
Origin-Date:50,300 YBP
Origin-Place:Southwest Asia
Ancestor:R2'JT
Descendants:J, T
Mutations:11251, 15452A, 16126[1]

Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.

Origin

Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.

Distribution

JT (predominantly J) was found among the ancient Etruscans.[2] The root level haplogroup JT* has been assigned to an ancient person found at the Colfiorito necropolis in Umbria in central Italy.

The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[3] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[4]

Subclades

Tree

This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation and subsequent published research.

Health

Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease[5] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[6] [7]

See also

References

  1. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Human Mutation. 13 Oct 2008. Mannis. van Oven. Manfred Kayser. 30. 2. E386–E394. 18853457. 10.1002/humu.20921. free.
  2. Web site: We Are Not Our Ancestors. 2012-02-10. 2009-04-08. https://web.archive.org/web/20090408043838/http://www.jogg.info/22/Coffman.htm. dead.
  3. Bernard Secher . Rosa Fregel . José M Larruga . Vicente M Cabrera . Phillip Endicott . José J Pestano . Ana M González . The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents. BMC Evolutionary Biology. 14 . 109 . 10.1186/1471-2148-14-109 . 24885141 . 4062890 . 2014 . 1 . 2014BMCEE..14..109S . free .
  4. Kefi, Rym. etal. On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations. Mitochondrial DNA Part A. 2016. 29. 1. 147–157. 10.1080/24701394.2016.1258406. 28034339. 4490910.
  5. Marom S, Friger M, Mishmar D . MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association . Sci Rep . 7 . 43449 . February 2017 . 28230165 . 5322532 . 10.1038/srep43449 .
  6. Martín-Jiménez R, Lurette O, Hebert-Chatelain E . Damage in Mitochondrial DNA Associated with Parkinson's Disease . DNA Cell Biol . 39 . 8 . 1421–1430 . August 2020 . 32397749 . 10.1089/dna.2020.5398 .
  7. Lowes H, Pyle A, Duddy M, Hudson G . Cell-free mitochondrial DNA in progressive multiple sclerosis . Mitochondrion . 46 . 307–312 . May 2019 . 30098422 . 6509276 . 10.1016/j.mito.2018.07.008 .

External links

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Haplogroup JT".

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