Haplogroup IWX (mtDNA) explained

In human genetics, Haplogroup IWX was a human mitochondrial DNA (mtDNA) haplogroup.^{[1] [2]}

It was thought to cluster haplogroups I, W, and X.^{[3] [4]} Studies suggested haplogroup IWX to be highly protective against AIDS progression.^[5] It is now known that Haplogroup I is descendant of Haplogroup N1. It has also been proposed that Haplogroup W be placed as a descendant of Haplogroup N2b.^[6]

Notes and References

1. Maruszak A, Canter JA, Styczyńska M, Zekanowski C, Barcikowska M . Mitochondrial haplogroup H and Alzheimer's disease--is there a connection? . Neurobiology of Aging . 30 . 11 . 1749–55 . November 2009 . 18308428 . 10.1016/j.neurobiolaging.2008.01.004. 5067976 .
2. https://books.google.com/books?id=LrgIQfwNS9cC&pg=PA484 The genome of Homo sapiens
3. Bermisheva M, Tambets K, Villems R, Khusnutdinova E . [Diversity of mitochondrial DNA haplotypes in ethnic populations of the Volga-Ural region of Russia] ]. Russian . Molekuliarnaia Biologiia . 36 . 6 . 990–1001 . 2002 . 12500536 . 2008-12-08 . 2023-11-30 . https://web.archive.org/web/20231130040255/http://evolutsioon.ut.ee/publications/Bermisheva2002.pdf . dead .
4. Simoni L, Calafell F, Pettener D, Bertranpetit J, Barbujani G . Geographic patterns of mtDNA diversity in Europe . American Journal of Human Genetics . 66 . 1 . 262–78 . January 2000 . 10631156 . 1288355 . 10.1086/302706 . 2008-12-08 . https://web.archive.org/web/20110716052516/http://web.unife.it/progetti/genetica/Guido/pdf/11.pdf . 2011-07-16 . dead .
5. Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, etal . Mitochondrial DNA haplogroups influence AIDS progression . AIDS . 22 . 18 . 2429–39 . November 2008 . 19005266 . 2699618 . 10.1097/QAD.0b013e32831940bb.
6. van Oven M, Kayser M . Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation . Human Mutation . 30 . 2 . E386–94 . February 2009 . 18853457 . 10.1002/humu.20921. 27566749 . free .