Hanneke Jansen Explained

Johanna M. Jansen, Ph.D.
Other Names:Hanneke
Alma Mater:Rijksuniversiteit Groningen, Uppsala University
Thesis Title:Three Dimensions in Drug Design: Probing the melatonin receptor
Thesis Url:https://www.bibliotheek.nl/catalogus/titel.13643908X.html/three-dimensions-in-drug-design/
Website:https://www.novartis.com/our-science/postdoc-program/leadership/johanna-hanneke-jansen-phd

Johanna Maria "Hanneke" Jansen is a computational chemist working at Novartis on multiple drug targets. She previously worked at Astra and at Chiron Corporation.[1]

Education

Jansen received her doctoral degree from the University of Groningen (The Netherlands) in 1995, studying computational medicinal chemistry. Her dissertation topic[2] concerned 3D modeling of the melatonin receptor, including work on synthesizing and separating analytes[3] [4] to probe its chemistry. She completed a postdoctoral fellowship at Uppsala University in 1997. Her work there related to modeling receptor interactions[5] of drug leads to judge their serotonergic or dopaminergic activities.

Research

Much of Jansen's oeuvre uses in silico methods to study receptor biology, drug design, and drug-protein interactions. An early study (2000) while she was employed at Chiron looked at conformations of the anti-cancer treatment Taxol in nonpolar environments.[6]

In a 2012 commentary for Future Medicinal Chemistry, Jansen led a team of distinguished computational chemists in a call to action, namely that standardized data sets be used across the industry, and that sharing program code between groups at different companies and institutions should be mandated.[7]

A 2017 open-access study in PLoS One related some of Novartis' work - spearheaded by Jansen - to study the oncogenic protein RAS through inhibitors that targeted its inactive conformations.[8]

Volunteer service

Jansen has served the ACS division on Computers in Chemistry since at least 2007, holding multiple leadership positions.[9] [10] Outside of pharmaceutical work, she is perhaps best known as a co-Founder and Steering Committee member for the Teach-Discover-Treat initiative,[11] which creates challenges for students and young professionals to design drugs against neglected diseases such as malaria or Trypanosoma using computational chemistry shared data sets and screens.

Awards

References

  1. Web site: Johanna (Hanneke) Jansen, Ph.D. Novartis. Novartis. en. 2018-12-01.
  2. Web site: Three dimensions in drug design. www.bibliotheek.nl. nl. 2018-12-01.
  3. Jansen. Johanna M.. Copinga. Swier. Gruppen. Gert. Isaksson. Roland. Witte. Dirk T.. Grol. Cor J.. 1994. Semipreparative enantiomeric separation of a series of putative melatonin receptor agents using tri-acetylcellulose as chiral stationary phase. Chirality. en. 6. 7. 596–604. 10.1002/chir.530060714. 7986673. 0899-0042.
  4. Witte. Dirk T.. Bruggeman. Frank J.. Franke. Jan Piet. Copinga. Swier. Jansen. Johanna M.. De Zeeuw. Rokus A.. 1993. Comparison between cellulose and amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phases for enantiomeric separation of 17 amidotetralins. Chirality. en. 5. 7. 545–553. 10.1002/chir.530050711. 0899-0042.
  5. Hedberg. Martin H.. Linnanen. Tero. Jansen. Johanna M.. Nordvall. Gunnar. Hjorth. Stephan. Unelius. Lena. Johansson. Anette M.. January 1996. 11-Substituted (R)-Aporphines: Synthesis, Pharmacology, and Modeling of D2Aand 5-HT1AReceptor Interactions. Journal of Medicinal Chemistry. en. 39. 18. 3503–3513. 10.1021/jm960189i. 8784448. 0022-2623.
  6. Snyder. James P.. Nevins. Neysa. Cicero. Daniel O.. Jansen. Johanna. February 2000. The Conformations of Taxol in Chloroform. Journal of the American Chemical Society. en. 122. 4. 724–725. 10.1021/ja9930115. 0002-7863. 2108/87943. free.
  7. Jansen. Johanna M. Amaro. Rommie E. Cornell. Wendy. Tseng. Y Jane. Walters. W Patrick. October 2012. Computational chemistry and drug discovery: a call to action. Future Medicinal Chemistry. en. 4. 15. 1893–1896. 10.4155/fmc.12.137. 23088271. 1756-8919.
  8. Jansen. Johanna M.. Wartchow. Charles. Jahnke. Wolfgang. Fong. Susan. Tsang. Tiffany. Pfister. Keith. Zavorotinskaya. Tatiana. Bussiere. Dirksen. Cheng. Jan Marie. 2017-04-06. Inhibition of prenylated KRAS in a lipid environment. PLOS ONE. en. 12. 4. e0174706. 10.1371/journal.pone.0174706. 1932-6203. 5383040. 28384226. 2017PLoSO..1274706J. free.
  9. Web site: 2007 Officers for COMP. Solutions. Allen Richon, Molecular. oldwww.acscomp.org. en-US. 2018-12-01.
  10. Web site: Officers in Past Years - ACS COMP Division. www.acscomp.org. 2018-12-01.
  11. Web site: Teach-Discover-Treat. www.teach-discover-treat.org. 2018-12-01.
  12. Web site: 2011 ACS Fellows - American Chemical Society. American Chemical Society. en. 2018-12-01.
  13. Web site: Awards - ACS COMP Division. web2011.acscomp.org. 2018-12-01.

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