| Handsome Brook | |
| Pushpin Map: | New York |
| Pushpin Map Caption: | Location of the mouth of Handsome Brook |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Subdivision Type4: | County |
| Subdivision Name4: | Delaware |
| Source1: | East Branch Handsome Brook |
| Source1 Coordinates: | 42.3043°N -75.0513°W |
| Source2 Coordinates: | 42.2801°N -75.0774°W |
| Mouth: | Ouleout Creek |
| Mouth Coordinates: | 42.3267°N -75.1913°W[1] |
| Mouth Elevation: | 1152feet |
Handsome Brook is a river in Delaware County, New York. It flows into the Ouleout Creek southwest of Franklin.